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Research Paper Open Access
Sixteen N'-alkyl and N'-aryl-N-[3-(2, 4-dialkoxy-5-alkylphenyl) propyl]-1, 2- diaminoethanes (IV) have been synthesised by treatment of 2,4-dialkoxy-5-alkylbenzene-propanoylchlorides with glycine followed by conversion of the resultant acids (III) into acid chlorides; condensation of acid chlorides with amines and LAH reduction of resultant diamides. The diamines isolated as dihydrochlorides have been tested in vitro for amoebicidal activity against E. histolytica.
DEpt. of Chemistry, University, of Jammu, Jammu-180 001