alexa Abstract | Synthesis and pharmacological activities of 2-methyl-8-quinolyloxypropylamines

Indian Journal of Pharmaceutical Sciences
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Starting chloropropane derivative (2) was prepared by the reaction of 2-methyl-8-hydroxyquinoline (1) with 1- bromo-3-chloropropane in presence of a base. Various new 1-(2-methyl-8-quinolyloxy)-3-propylamines (3a-3j) have been synthesized by the condensation of 1-(2-methyl-8-quinolyloxy)-3-chloropropane (2) with different amines. Compounds were screened for the possible central nervous system depressant activities. Some of them showed moderate central nervous system depressant activity.

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Author(s): YSR Reddy MD Afzal Azam JT Leonard B Suresh IE Chakravarthy

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