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Research Paper Open Access
5-Substituted-2-phenylindol-3-carboxaldehydes (1a-c) were reacted with substituted acetophenones in ethyleneglycol in presence of piperidine to yield the respective chalcones (3ar). When these chalcones were reacted in absolute ethanol with orthophenylene diamine produced 7-substitutedphenyl-5-(5'-substituted-2'-phenylindol-3'-yl)-l,4-benzo[b]diazepines (4a-r). The structures of the newly synthesised compounds were elucidated on the basis of analytical and spectral data. These compounds have been screened for analgesic, antiinflammatory and locomotor activities.
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Author(s): J S Biradar S Y Manjunath