alexa Abstract | Synthesis And Pharmacological Evaluation Of 1-[2,6,8-Trisubstituted â??4(3H)-Oxoquinazolin-3-Yl]-3-(4-Substituted Phenyl) Thiobarbiturates

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


Twelve new 1-[2,6,8-trisubstituted-4(3H)-oxoquinazolin-3-yl]-3-(4-substituted phenyl) thiobarbiturates (17-28) were synthesized by reacting 2, 6,8-trisubstituted-3-[N3-(4-substituted phenyl) thioureido]-4(3H)-quinazolones (5-1 6) with malonic acid in presence of acetyl chloride. These thioureidoquinazolone intermediates were obtained, on the other hand, by the condensation of 3-amino-2,6,8-trisubstituted-4(3H)- quinazolones (1-4) with different 4-substituted phenyl isothiocyanates. All these compounds were characterized by analytical and spectral data. Compounds 27, 24 and 20 were found to possess good sedative properties while compounds 18, 26 and 28 exhibited significant anticonvulsant activity.

To read the full article Peer-reviewed Article PDF image

Author(s): G V S Rama Sarma J Vekateswara Rao B Suresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version