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Research Paper Open Access
Naphtho[2,1-b]furyl-2-carboxyhydrazide 1 has been condensed with various substituted acetophenones to obtain corresponding carboxy hydrazones 2, which on treatment with Vilsmeier-Haack reagent resulted in the formation of 2-[3-phenyl-4-formyl -1-carbonyl]naphtho[2,1-blfuran pyrazole derivatives 3a-f. The compound 1 has been converted into N-aroyl-N'-(naphtho[2,1-b]furan- 2-carbonyl)hydrazine 4a-c, which on cyclization with phosphorous oxychloride produced 2-[5- aroyl-1,3,4-oxadiazol-2-yl]naphtho[2,1-b]furans 5a-c. The compound 6 has been synthesized by the condensation of 1 with ethyl acetoacetate. Various naphtho[2,1-b]furan-2-[N'-(substituted benzopyran-2'-one-3'-carbonyl)]hydrazides 8a-d, have been prepared from compound 1 via compound 7.The compounds 8a-d have also been synthesized by direct condensation of 1 with 6- substituted coumarins. All newly synthesized compounds have been characterized by elemental analysis and spectral data and screened for antimicrobial, anthelmintic, antiinflammatory, analgesic and diuretic activities.
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Author(s): KM Mahadevan VP Vaidya