alexa Abstract | Synthesis and screening of pyrazole based cinnoline derivatives for its antitubercular and anti-fungal activity

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access


A Series of 4-methyl-3-[5-(substituted phenyl)-4, 5-dihydro-1H-Pyrazol-3-yl] cinnoline-6-Sulfonamide were synthesized from 4-methyl-3-acetylcinnoline-6-Sulfonamido chalcones and hydrazines. The structure of the synthesized compounds were characterized by UV, IR, NMR & Mass spectral data, and evaluated for their in vitro anti-tubercular and anti-fungal activity. Compound CN-5a was most potent against Mycobacterium tuberculosis H37Rv, and all the analogues showed good anti-fungal activity against various pathogenic fungi.

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Author(s): S Hurmath Unnissa and T K Ravi


Cinnoline, Pyrazole, Chalcones, Anti-tubercular, Anti- fungal, anti-fungal activity

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