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Original Articles Open Access
In present study a series of sorbic acid (2,4-hexadienoic acid) hydrazide-hydrazone derivatives was synthesized and screened for their in vitro antibacterial potential against Gram-negative Escherichia coli and Gram-positive Bacillus subtilis, Staphlococcus aureus and Staphlococcus epidermidis by tube dilution method. Molecular docking study was also performed as potential FabH inhibitor. The results of antibacterial screening showed that the compounds having electron withdrawing groups viz. NO2 (4 and 11), Br (10) and electron donating groups viz. p- OCH3, m-OC2H5 (8) are more active against tested bacterial strains as compared to other synthesized derivatives and may be further developed as antibacterial agent. Moreover, compounds 4 and 11 were pointed to be most active against all tested bacterial strains with MIC value ranging from 0.023 to 0.46 μM/ml. Docking studies revealed that dipolar interactions with amino acid residues (Cys112 and Ala246) and H2O of FabH found to be crucial and results are comparable with in vitro antimicrobial activities of synthesized derivatives.
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Author(s): Yusuf Adamu Muhammad Rakesh Narang Surendra Kumar Nayak and Sachin Kumar Singh
Sorbic acid, 2,4-Hexadienoic acid, Hydrazide, Antibacterial, Molecular docking, antibacterial