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Short Communication Open Access
A series of novel 2,3-disubstituted/6,8-dibromo-2,3-disubstituted quinazolin-4(3H)-ones have been synthesized by condensing the primary amino group of lamotrigine with benzoxazin-4-one.The structure of the synthesised compounds was elucidated by spectral analysis (IR, NMR and Mass). The compounds synthesized were screened for antibacterial and antiHlV activities against replication of HIV-1 and HIV-2 in acutely infected LIT-4 cells. The compounds SPC-I, SPC-I Brand SPCIII Br (100 Î¼g/ml) exhibited equivalent antibacterial activity with the standard ciprofloxacin (10 Î¼g/ ml) against salmonella typhi. All the compounds exhibited cytotoxic properties in the MT-4 lymphocyte cell line.
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Author(s): P Selvam K Girija G Nagarajan E De Clercq