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Research Paper Open Access
New derivatives of ketoprofen and flurbiprofen were synthesized by Mannich reaction. The Mannich base amides of ketoprofen and flurbiprofen were synthesized using different amines. These were then evaluated for analgesic, anti-inflammatory, ulcerogenic activities and quantitative structure-activity relationship was analysed. Some of the derivatives were found to be potent with practically no ulcerogenic activity.
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Author(s): N Kawathekar S C Chaturvedi