alexa Abstract | Synthesis, characterisation, antimicrobial activity, DNA cleavage studies on binary complexes of Cu(II), Ni(II), Co(II) and Ru(II) with (R)-N-(phenyl)ethyl-5-chloro-2-hydroxy-1-salicylaldimine schiff base

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


A series of binary complexes of Co(II), Ni(II), Cu(II) and Ru(II) with (R)-N-(phenyl)ethyl-2-hydroxy-1- salicylaldimine (L or NPEHS) have been synthesised. The Ligand (NPEHS) is co-ordinated to the metal ion with the N, O donor atoms in 1:2 (metal : ligand) ratio and it is determined by spectrophotometric studies. The resulting metal complexes of NPEHS were characterised by the FT-IR, UV-Vis, TGA, elemental analysis, conductivity measurements and ESR spectral studies. Conductometric measurements confirm all the metal complexes were nonelectrolytic in DMSO. Based on spectral and analytical data octahedral geometry is assigned to the complexes with two coordinated water molecules. The stoichiometry of the resulting complexes have been found to be [M(L)2(H2O)2], here M = Co(II), Ni(II), Cu(II) and Ru(II). The in-vitro antimicrobial studies performed through the Disc Diffusion Method revealed that the complexes have shown better antimicrobial activity than free ligand. DNA cleavage of metal complexes are also confirmed through the gel electrophoresis technique. It is found that these complexes effectively cleave the DNA.

To read the full article Peer-reviewed Article PDF image

Author(s): Jagadish Tota Haritha Mahajan and Satyanarayana Battu


Binary metal complexes, spectral analysis, antimicrobial activity, spectrophotometry and DNA cleavage., DNA cleavage, schiff base

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us