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Research Paper Open Access
In the present study, a novel series of 2-methyl-qninazolin-4(3H)-ones were synthesized and characterized by IR, 1H-NhlR, 13C-NMR and mass spectral analysis. The synthesized compounds were screened for analgesic (100, 200 and 400 mg/kg), antiinflammatory (200 and 400 mg/kg), antibacterial (Bacillus subtilis, Bacillus cereus, Staphylococcus epidermidis, Micrococcus Iufeus and Escherichia coli) and antifungal (Candida albicans and Aspergillus niger) activities. The minimum inhibitory concentrations of the compounds were also ascertained by agar dilution method. Graded dose response was observed with the compounds. 6,8-dibromo-2-methyl-3-(4'-morpholino-phenyl)- 4(3H)-one (2) exhibited the highest analgesic and antiinflammatory activity. 6-Bromo-2-methyl- 3-(4'-morpholino-phenyl)-quinazolin-4-(3H)-one (1) was found to exhibit the highest antimicrobial activity. All the compounds exhibited significant activity against the bacteria and fungi tested.
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Author(s): P Panneerselvam RV Pradeepchandran SK Sridhar