alexa Abstract | Synthesis, characterization and biological studies of novel fused thiazolidinone derivatives

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access

Abstract

Several fused heterocycles based on thiazolidinone derivatives were synthesized and characterized using physical properties, elemental analysis, IR and other spectral studies. New ligands i.e. 4-(2-furyl)-6-methyl-2-oxo- N-(3,5- diaryl-2- phenyl-3,3a- dihydro-2H- pyrazolo [3,4-d][1,3] thiazol-6(5H)-yl)-1,2,3,4-tetrahydro pyrimidine-5- carboxamide (5a-h) were synthesized by condensation reaction of thiazolidinone derivatives with phenyl hydrazine in presence of glacial acetic acid. Furthermore the antibacterial and antifungal activity of newly synthesized fused heterocyclic compounds was examined against various microbial strains.

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Author(s): Suresh P Jambu and Yogesh S Patel

Keywords

Fused heterocycles, Thiazolidinone derivatives, Spectral studies, Antibacterial activity, Antifungal activity, thiazolidinone

 
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