alexa Abstract | Synthesis, characterization and inhibitory activity against breast carcinoma cells of a new Azo-Ligand and its Metal complexes

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

A novel azopyrimidin ligand N-(1-(4-aminophenyl)ethylidene)-4-(2-amino-3-(4-methoxyphenyl)diazenyl)[1,5- a]pyrimidin-7-yl)benzeneamine. The prepared azo-ligand was used for further complexes formation reaction with different metal ions using Ni(II)(CH3COO)2, Cu(II)(CH3COO)2, Pd(II)Cl2, Ag(I)NO3, Pt(IV)Cl4 and HAu(III)Cl4 by a molar ratio of ligand : metals. The stereochemistry and the mode of bonding of the complexes were achieved based on elemental analysis, IR, UV-Vis, 1HNMR and MS as well as thermo-gravimetric analysis (TGA). Structures proposed for geometry of the chelates based on their electronic spectra and magnetic moment. The metal complexes possessed an tetrahedral for [Ni(II) and Cu(II)], square planer for [Pd(II), Pt(IV) and Au(III)] and a triagonal geometry for Ag(I). The solid complexes have been synthesized and studied by TGA analysis. The thermal dehydration and decomposition of these complexes were studied kinetically using the integral method applying the Coats–Redfern and Horowitz Metzeger equation. The band gap energy values of all compounds are characteristic of semiconductor materials. The metal complexes show inhibitory activity against breast carcinoma cells.

To read the full article Peer-reviewed Article PDF image

Author(s): Ali M Hassan Bassem H HeakalTamer M Kehela O A Fouad and A Mohy Eldin

Keywords

Azo pyrimidine, Breast cancer, Thermal kinetics, Band gap Energy, carcinoma cells

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords