alexa Abstract | Synthesis, Characterization, Antimicrobial Studies And Pharmacological Screening Of Some Substituted 1,2,3-Triazoles

Indian Journal of Pharmaceutical Sciences
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A few substituted 1,2,3-triazoles have been synthesized by the 1,3-dipolar cycloaddition of azides with substituted acetylene. The cycloaddition of some amido alkyl azides with dimethylacetylene dicarboxylate furnish 1,4,5-trisubstituted triazoles. Three new 2-(4,5-dicarbomethoxy-1,2,3-triazol-1-yl)-N-(substituted aryl) acetamide were synthesized, represented as IIIa, IIIb and IIIc in which R=OCH3, CH3 and H respectively. The products have been characterized by IR, PMR and Mass spectra. All the three compounds were screened for antimicrobial (antifungal and antibacterial) activities. All of these exhibit antimicrobial activities comparable with standard drugs. Among the three, the compound IIIa shows more antimicrobial activities. Therefore, the same compound was taken for detailed pharmacological screening including, analgesic, antiinflammatory, local anaesthetic and antihistaminic activities. The compound answers for analgesic, antiinflammatory and local anaesthetic activities comparable with standard drugs but failed to show any antihistaminic activity.

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Author(s): K Masna Banu A Dinakar C Ananthanarayanan

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