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Research Paper Open Access
Several 1-(substituted thioanilido)-8-Keto-3-substituted benzopyridazines (III) were readily synthesized by cyclodehydration of corresponding 4-aryl thiosemicarbazones (II) which were prepared by condensation of either 2-carboxy benzaldehyde or 2-carboxy benzophenones with 4-aryl thiosemicarbazides. Twenty-one such compounds have been tested for general pharmacological properties on cardiovascular system in guinea-pigs. These compounds were found to have positive inotropic activity in vitro.