alexa Abstract | Synthesis of 2,4,5-Triaryl-1H-Imidazoles using anhydrous PbCl2

Journal of Chemical and Pharmaceutical Research
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A simple and versatile synthesis of 2,4,5-Triaryl-1H-imidazole derivatives is achieved by pathway of Multicomponent reaction involving cyclocondensation of 1,2-dicarbonyl compound, aromatic aldehyde and ammonium acetate as a source of ammonia in presence of anhydrous PbCl2 as a catalyst in ethyl alcohol. The remarkable features of this synthetic pathway are simple workup, short reaction time, high yields and use of anhydrous PbCl2 as an effective catalyst.

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Author(s): Vishvanath D Patil Nagesh R Sutar and Ketan P Patil


2, 4, 5-Triaryl-1H-imidazole, Multicomponent reaction, anhydrous PbCl2, high yields, effective catalyst., PbCl2

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