alexa Abstract | Synthesis of 2-phenyl-3H-dipyrimido[1,2-a] pyrimidin-4(5H)-one derivatives and their antifungal activity

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access

Abstract

Some 2-phenyl 3H-dipyrimido[1,2-a] pyrimidin -4(5H)-one derivatives were synthesised by the reaction of pyrido[1,2-a]pyrimidine 3-carbonitrile with benzoic acid in the presence of catalytic amount of Amberlyst 15–wet (strongly acidic) in green reaction medium i.e. PEG-400. The structural elucidation of the compounds was performed by spectral analysis. All the synthesized compounds were screened for their antifungal activity. Most of compounds show excellents activity .

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Author(s): Shrikant V Hese Rahul D Kamble Pratima P Mogle Sonali S Kamble Madhav J Hebade Ajay N Ambhore Shiddhodan N Kadam Rajesh NGacche and Bhaskar S Dawane

Keywords

2-phenyl 3H-dipyrimido[1,2-a]pyrimidin-4(5H)-one derivatives, PEG-400, Amberlyst 15-wet (Strongly Acidic), Antifungal activity., antifungal

 
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