alexa Abstract | Synthesis of 2-substituted methylthieno [2,3- d]pyrimidin-4(3 h)-ones and evaluation for antihyperlipidemic activity

Indian Journal of Pharmaceutical Sciences
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A series of nicotinyl 4-oxathieno[2,3- d ]pyridine-2-ylmethyl esters, title compounds were synthesized. Compound IIIa was subjected to in vivo antihyperlipidemic activity in Wistar rats. The activity exhibited by synthesized compound was found to be less as compared to that produced by a standard, atorvastatin, administered in the form of suspension in 2% gum acacia. The activity was even lesser than that produced by the lead IIa.

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Author(s): PR Murumkar RA Fursule KS Jain SJ Surana

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