alexa Abstract | Synthesis of 3,6-dialkyl-7-hydroxy-4-methyl-2h-1-benzopyran-2-ones and related compounds as anticoagulants.

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access


The title compounds were synthesised by the condensation of ethyl alpha-propyl/isopropyl/n-butylacetoacetate (13-15) with disubstituted phenols (1-12) in presence of POCL3 or 73 percent H2SO4. Compounds 25, 27 and 39 prevented in vitro clotting of blood for 40, 120 and 30 min. respectively. In gross behavioural effects, compound 35 was found to be depressant while 36-38 were stimulants. Rest of the compounds did not show any significant activity.

Author(s): OP Malik BB Gupta V Abrol

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