alexa Abstract | Synthesis of 5-methyl-4-thio-6-(1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidines and their antimicrobial activity study

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Interaction of 5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid with benzohydrazide promoted by 1,1’-carbonyldiimidazole leads to N'-benzoyl-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6- carbohydrazide. The cyclization of the hydrazide with phosphorous oxychloride resulted in the unstable 4-chloro-5- methyl-6-(5-phenyl-1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidine, which formed 5-methyl-6-(5-phenyl-1,3,4- oxadiazol-2-yl)thieno[2,3-d]pyrimidine-4(3H)-thione after reaction with thiourea in dimethylformamide. All of the compounds tested showed moderate unspecific antimicrobial activity against the strains of bacteria and fungi similar to Synthomycine an higher then Streptomycin against Proteus vulgaris and Pseudomonas aeruginosa.

To read the full article Peer-reviewed Article PDF image

Author(s): Sergiy V Vlasov Sergiy M Kovalenko Valentin P Chernykh and Konstantin Yu Krolenko

Keywords

thiophene, pyrimidine, cyclization, oxadiazole, alkylation, antimicrobial

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords