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Research Paper Open Access
A series of beta-D-glycopyranosyl xanthotoxol derivatives has been synthesised and screened for CNS depressant activity. The more active CNS depressant,9-beta-D-arabinopyranosyl xanthotoxol (IX), was selected for detailed study on different pharmacological parameters. It caused dose dependent inhibition of spontaneous motor activity, prolongation of hexabarbitone, pentobarbitone and ether hypnosis.