alexa Abstract | Synthesis of a new series of 1-(arylideneamino)-3-(4'-substituted sulphone)-guanidines as hypoglycemic agents

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

Eight title compounds were synthesized by refluxing 1-(arylidene)-S-methylthiosemicarbazide with appropriate sulphonamides and their structures established by elemental analyses and spectral (IR, PMR) studies. In pharmacological screening, the compounds showed a reduction in blood glucose level upto 25 in rats at an oral dose of 250 mg/kg (tolbutamide 40 percent)



Author(s): VR Agarwal DD Mukerji

 
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