alexa Abstract | Synthesis of Azole Derivatives of l-Proline and their Antibacterial Activity

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


Four azole derivatives of proline, namely 2-[2-( 1,3,4-oxadiazol-5-thionyl)]proline 5, 2-[2-( 4-N-amino-1,2,4- triazol-5-thiolyl)] proline 6, 2-[2-(1,2,4-triazol-5-thiolyl)] proline 7 and 2-[2-( 1,3,4-thiadiazol-5-thionyl)] proline 8 have been synthesized from proline 1via a common synthetic pathway. IR, 1H-NMR, 13C-NMR and DEPT-NMR, characterized all intermediates and final products. The antibacterial activities assessed using the paper disk diffusion method against Gram-negative bacteria: Pseudomonas aeruginosa and Escherichia coli and Grampositive bacteria, Bacillus cereus, and Staphylococcus aureus. Some of the synthetic compounds showed promising activity against microorganisms under test in comparison to commercially available antibiotics ampicillin and gentamycin.

To read the full article Peer-reviewed Article PDF image

Author(s): Lemia Amarouche Fawzia Taieb Brahimi and Adil A Othman


Proline amino acid, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,4-triazole, antibacterial activity, Azole Derivatives

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us