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Original Articles Open Access
N-(2-nitrophenyl) pyrazine-2-carboxamide and N-(4-nitrophenyl) pyrazine-2-carboxamide synthesized and studied as an anti-tuberculosis agents using in-silico and in-vitro analysis. In-silico study reveals the inhibition of Mycobacterium tuberculosis mycolic acid cyclopropane synthase CmaA2 (PDB Code : 3HEM) by both compounds. Whereas in-vitro study, reveals the inhibition of M. tuberculosis H37Rv occurred at concentrations ≥32 μg/ml for n- (2-nitrophenyl) pyrazine-2-carboxamide only.
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Author(s): Patil S U and Ganatra S H
Mycobacterium, Tuberculosis, Inhibition, Drug, Enzyme, N-phenyl pyrazine-2-carboxamide, Mycobacterium, Tuberculosis, Inhibition, Drug, Enzyme, N-phenyl pyrazine-2-carboxamide