alexa Abstract | Synthesis of new 1, 3, 4-oxadiazolo [3, 2-a]-s-triazine-5, 7-dithiones and the - dithionone analogues as potential antifungal agents.

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access


N1-Aryl-N3-(5-aryl-1, 3, 4-oxadiazol-2-yl) thioureas (II a-d) on cyclocondensation with CS2/KOH and ethyl chloroformate afford 2, 6-diaryl-1, 3, 4-oxadiazolo [3, 2-a]-s-triazine-5, 7-dithiones (III a-d) and their - thionones analogues (IV a-d) respectively. 2, 6-Diaryl-5-thioxo-1, 3, 4-oxadiazolo [3, 2-a]-s-triazin-7-ones (VI a-d) are obtained by trating oxadiazolycarbamates (V a-b), the condensation products of 1, 3, 4-oxadiazoles and ethyl chloroformate, with aryl isothiocyanates. The compounds II to VI have been screened for their antifungal activity against A. flavus and F. solani.

Author(s): H Singh L DS Yadav KN Shukla R Dwivedi

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