alexa Abstract | Synthesis of novel Sultams containing thiazolidin-4-one heterocycles

Journal of Chemical and Pharmaceutical Research
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Abstract

Novel Thiazolidin-4-one Synthesis of 3-(2-(1,1-dioxido-1,2- thiazetidin-2-yl)ethyl)-2-phenylthiazolidin-4-one 8 (af) were synthesized by condensation reaction between synthesis of 2-(2-(4-substituted benzylideneamino)ethyl)-1,2- thiazetidine 1,1-dioxide 6(a-f) and a mixture of mercaptoacetic acid and anhydrous Zinc chloride. Synthesis of 2-(2- (4-substituted benzylideneamino)ethyl)-1,2-thiazetidine 1,1-dioxide 6(a-f) was condensed with 4-substituted benzaldehyde in absolute alcohol. The synthesis of 2-(2-aminoethyl)-1,2-thiazetidine 1,1-dioxide(4) was synthesized by condensation of synthesis of 1,2-thiazetidine 1,1-dioxide (β-Sultam)(3) a mixture of K2CO3, TEBA , Acetonitile and 2-chloro ethanamide. Synthesis of 1,2-thiazetidine-1,1-dioxide(β-Sultam) (3) was synthesized with Taurinesulfonylchloride (2) with Na2CO3, Ethyl acetate. Taurinesulfonylchloride (2) was synthesized by S-S bond cleavage Cystaminedihydroxychloride (1) with mixture of Chlorine gas, Chloroform and Ethanol solvent mixture.

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Author(s): P Ramesh Babu B Saritha D Rajesh and L K Ravindranath

Keywords

Sultam, Thiazolidin-4-one, Cylization, Antibacterial and antifungal activity, thiazolidin-4-one heterocycles

 
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