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Short Communication Open Access
Propafenone, an antiarrhythmic agent belonging to class I C was synthesized by two different methods starting from phenol. Method-1 involving initial formation of chalcone from o- hydroxyacetophenone was superior over methods-2 with respect to yield and reaction process. In method-2, the oxypropanolamine chain was built and then aldol condensation was carried out.
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Author(s): V D Patil C L Viswanathan