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Original Articles Open Access
5-Amino pyrazole 4 was transformed to pyrazolo pyridine derivatives 7 by microwave irradiation with diethyl malonate. Alternatively it was synthesized by two step process through open chain derivative 6 then it was transformed to 7 by refluxing in biphenyl ether. N- Alkylation reaction on 7 was studied by ethyl bromo acetate and also by microwave irradiation. The pyran ring was annulated on 7 by condensing it with by benzilidine malononitrile. All synthesized compounds were characterized by spectral and analytical methods. It was noted that synthesis and alkylation of 7 was performed in microwave and it is faster than conventional method. The biological activity of compounds 7, 9 and 11 were studied.
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Author(s): Sunita A Chaudhari Patil Sandeep R Patil Vasant M Patil Sambhaji V PatilMadhukar N Jachak and Ashok Desai
Microwave irradiation technique, green approach, 5-amino pyrazole, pyranofused hetrocycles, ethyl bromo acetate, benzilidine malononitrile, Chemical synthesis