alexa Abstract | Synthesis of some new chalcone derivatives and evaluation of their Anticancer activity

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Chalcones which are also known as α,β-unsaturated ketones is an important class of organic compounds and reported to possess a wide spectrum of biological activities such as antibacterial, antifungal, anticancer, anti-inflammatory etc. The biological activity of chalcone is mainly because of an enone pharmacophore in their structures, the importance of which is well documented in the literature. Although a number of drugs are available in the market, the thirst for discovering a new drug with better pharmacokinetic profile, lesser toxicity has become imperative for obvious reasons and also due to the fast development of microbial resistance towards existing molecules. Therefore in the present study some novel chalcones have been synthesized for biological activities like anti-cancer , antibacterial and antioxidant activity. Cyclic ketones having α-hydrogens was treated with various aromatic aldehydes in alcohol, in the presence of potassium hydroxide to form corresponding α,β-unsaturated compounds. The structures of these compounds are supported by their UV, IR, NMR and Mass spectral data. The compounds have been evaluated for their anti-cancer, antibacterial and antioxidant activities.

To read the full article Peer-reviewed Article PDF image

Author(s): Afzaye Rasool Rakesh Panda andDr Monica Kachroo

Keywords

Chalcones, anticancer, antibacterial, antioxidant

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psych[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords