alexa Abstract | Synthesis of water soluble transition metal(II) complexes from morpholine condensed tridentate schiff base: Structural elucidation, antimicrobial, antioxidant and DNA interaction studies

Journal of Chemical and Pharmaceutical Research
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Abstract

A new series of water soluble transition metal Cu(I I), Co(II), Ni(II), Mn(II) and Zn(II) complexes hav e been synthesized from 2-(2-Morpholinoethylimino)methyl)p henol Schiff base ligand (LH) in a 1:2 molar ratio. The resulting compounds were characterized by elemental analysis, Magnetic susceptibility, Molar conductan ce, IR, UV-Vis, 1 H NMR, EPR and ESI-Mass Spectral techniques. The sp ectral data of these complexes suggest an octahedral geometry around the central metal ion an d found to possess [ML 2 ] stoichiometry. In vitro antimicrobial activities of all compounds were examined against s elected bacterial and fungal strains by the disc di ffusion method which indicates that the complexes exhibit higher a ntimicrobial activity than free ligand. The DNA cle avage activity of all compounds was monitored by the agarose gel e lectrophoresis method using Calf – Thymus DNA. In t his result Cu(II), Co(II ) and Ni(II) complexes showed a signi ficant cleavage property than others. In vitro anti oxidant and DNA-binding properties of these complexes have been investigated by electronic absorption technique. T he intrinsic binding constant (K b ) values of Cu(II), Co(II) and Ni(II) complexes are found as 1.1461 X 10 5 , 5.1063 X 10 4 and 2.4324 X 10 4 M −1 respectively. The binding affinity to DNA has been investigated by viscosity titration measurements, The binding affinity values of these complexes were slightly lower than those observed f or classical intercalator (Ethidium bromide-DNA) and observed in the order of EB > Cu(II) > Co(II) > Ni(II)>Zn(II)> Mn(II). The experimental results suggest that the complexes bind to DNA via intercalation.



Author(s): Jeyaraj Dhaveethu Raja and Karunganathan Sakthikumar

Keywords

Schiff base, Octahedral, Antioxidant, Antimicrobial, DNA interaction., water soluble transition metal(II), morpholine, tridentate.

 
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