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Research Article Open Access
4-chloroaniline reacts with 1-(4-hydroxyphenyl)-ethanone in presence of 1-napthonicacid and copper metal as a catalyst gives 1-(4-(4-aminophenoxy) phenyl)ethanone, which on further condensation with 4-nitrotoluene-2- sulfonyl chloride gives N-(4-(4-acetylphenoxy)phenyl)-2-methyl-5-nitrobenzenesulphonamide. This derivative react wit various substituted aldehydes to give corresponding substituted chalcone derivatives (N-1). Now these derivative (N-1) on condensation with NH2CONH2 in presence of dilute HCl gives 2-methyl-5-nitro-N-(4-(3-(2-oxo-6-phenyl- 1,2,5,6-tetrahydropyrimidin-4-yl)phenoxy)phenyl)benzenesulfonamide (N-2). Structure elucidation of synthesized compounds has been made on the basis of the elemental analysis, 1H NMR spectral studies. The antimicrobial activity of the synthesized compound has been studied against the species Bacillus subtillis, Staphylococcus aureus, Escherichia coli and Salmonella typhi.
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Author(s): Rajarshi N Patel and Piyush V Patel
Chalcone derivates, Antimicrobial agents,Synthesis, heterocyclic substituted chalcone derivative,sulphonamide derivatives, pyrimidin derivatives, antimicrobial activity