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Research Paper Open Access
Tamarind seed polyose (TSP), a polysaccharide obtained from the seeds of Tamarindus indica was studied for sustaining the release of verapamil hydrochloride. The release pattern was compared with matrices of other polysaccharide polymers such as ethyl cellulose, hydroxyethyl cellulose and hydroxypropyimethyl cellulose, as well as the commercially available sustained release tablets (Isoptin SR). Formulation was also done by substituting part of the polymer with ethylhydroxyethyl celluose for enhancement of the drug release. The in vitro release of the drug from the matrices prepared were studied using the Sartorius Dissolution Simulator. Two formulations, found comparable to Isoptin SR were subjected to in vivo studies in rabbits. The results indicated a good correlation between in vitro and in vivo studies.
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Author(s): D Kulkarni A K Dwivedi J P S Sarin S Singh