alexa Abstract | Temozolomide as Treatment in Lowgrade Glioma: A Systematic Review

Neuro-Oncology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Background: With the advent of newer chemotherapeutic agents, the use of Temozolomide is becoming an option in the treatment of low-grade glioma (LGG). This systematic review aims to look into the available evidences on the efficacy of Temozolomide in the management of LGG and determine if it is a good and reasonable option for the patients. Method: A literature search and systematic review was conducted primarily answering the question: “What is the efficacy of Temozolomide in the treatment of LGG?” A two-phase abstraction was utilized yielding a total of nine studies included in the review. Results: Ten prospective single-arm studies were initially included but one study was adjudicated as having low quality. Nine studies involving 453 patients with LGG were included. In this review, the three-year overall survival of patients diagnosed with LGG who were given Temozolomide were noted to be high ranging from 73.1-82.0% while progression-free survival showed a wide variation across studies ranging from 11.0-98.0%. Reduction in seizure frequency was seen in 48- 62% of the patients. The occurrence of mild to moderate hematologic toxicity is quite common at 10-97%. Conclusion: We conclude that Temozolomide showed consistently high overall survival and reduction in seizure frequency among patients diagnosed with LGG. Variable responses on objective radiologic response, quality of life and progression- free survival rates were noted. Future studies should look into the efficacy of Temozolomide as an adjunct or as an initial treatment in LGG with a comparison with a control group in order for more conclusions to be made.



Author(s): Ranhel C De Roxas Cezar Thomas R Suratos and Marc Laurence L Fernandez

Keywords

Temozolomide, Low-grade glioma, Chemotherapy, Astrocytomas, Brain tumor, Glioma, Glioblastoma multiforme (GBM)

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords