alexa Abstract | The comparative effect of hydro alcoholic extract of passion flower and fluoxetine on depression symptoms in mice by the tail suspension test

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


The present study was to compare the effect of passion flower’s extract and fluoxetine on depression symptoms in mice using Tail suspension test. In this empirical study, number of 50 mature mice (weight range of 25 to 30 gr) was used in five groups. Depression symptoms were observed in four groups, after injection of 25 mg/ kg tetrabenazine. Three groups has been received 50, 100 and 200 mg/ kg hydro alcoholic extract of passion flowers as for rat's weight via intraperitoneal injection. Group four has been received 1.4 mg/kg fluoxetine, while group five as control ones received no treatment. The Tail suspension test was used to assess depression mood, and increase in the movement time to second and decrease of time to moveless assigned as an index for depression. The SPSS software was used for analyzing collected data. Compare to control group and fluoxetine, hydro alcoholic extract of passion flower’s with concentration of 50 and 100 mg/kg of mice weight has been significantly increased time of movement and decreased time of moveless in samples; and these all shows depression mood. The results of this study suggest that 50 and 100 mg/kg hydro alcoholic extract of passion flower can be an appropriate alternative for fluoxetine to decrease depression symptoms (p˂0.05).

To read the full article Peer-reviewed Article PDF image

Author(s): Zahra Dalvand Mehrdad Modaresi and Ilnaz Sajjadian


depression, fluoxetine, passion flower’s, Tail suspension test, hydro alcoholic extract

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version