alexa Abstract | The effect of adrenaline or noradrenaline with or without lidocaine on the contractile response of lipopolysaccharide-treated rat thoracic aortas.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


The analgesic effect of a local anesthetic is often insufficient in acutely inflamed tissues, due to the reduced pH and/or vasodilation. Thus, vasoconstrictors (adrenaline or noradrenaline) are often used to contain the anesthetic and prolong the analgesia, although there are minimal data regarding their effects in inflamed tissues. Therefore, we prepared a model of blood vessel inflammation (using lipopolysaccharide), and investigated the contractile effects of adrenaline or noradrenaline with and without lidocaine. Wistar rats’ thoracic aortas were cut into 3-mm-thick rings, which were stretched using a pair of hooks in an organ bath (Krebs-Henseleit solution, 37°C, pH=7.4). After lipopolysaccharide exposure (1 μg/mL), adrenaline or noradrenaline was applied in successive cumulative doses (10-9 to 10-5 M) with or without lidocaine (10-4 M), and the isometric vasocontractions were recorded. The lipopolysaccharide treatment attenuated the vasocontractions that were induced by adrenaline or noradrenaline with lidocaine in a time-dependent manner. Despite its vasodilation properties, lidocaine enhanced the contractile responses that were produced by low concentrations of adrenaline (10-8 to 10-7 M), which indicates that a sufficient analgesic effect depends on the concentration of lidocaine and adrenaline. Therefore, adrenaline should be used when injecting inflamed tissues with lidocaine.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Shigeki Fujiwara Akiko Noguchi Masanori Tsukamoto Shinichi Ito Uno Imaizumi Yoshinari Morimoto Kazuichi Yoshida Takeshi Yokoyama


Lipopolysaccharide, Lidocaine, Vasoconstriction, Adrenaline, Noradrenaline, #

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version