alexa Abstract | The effect of anabolic steroid nandrolone decanoate on exercise-induced hypoalgesia: Role of opioid peptides

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


A number of athletes abuse anabolic steroids to improve muscle performance. It has been shown that supratherapeutic doses of these substances can effect on opioidergic system. It is well known that aerobic exercise has hypoalgesic effects, which proposed to be related to activation of opioidergic system. In this study, the chronic effects of nandrolone decanoate on nociception, β-endorphin and met-enkephalin levels in exercised rats were evaluated. For our aims, both Sedentary (S) and trained (T) male rats received daily injections of nandrolone (15 mg/kg, 5 times/week) or vehicle. After two weeks, nociceptive threshold was estimated by tail flick test, and Circulating levels of β-endorphin and met-enkephalin were determined using ELISA method. Results showed that two weeks of swimming exercise training, were significantly increased nociceptive threshold and serum opioid peptides levels. Administration of nandrolone decanoate was significantly decreased nociceptive threshold and opioid peptides levels in trained group; despite its decline, the effect of nandrolone decanoate in sedentary group was not statistically significant. In conclusion, these findings revealed that two weeks administration of nandrolone decanoate can reduce the plasma opioid peptides level as well as exercise induced hypoalgesia in trained rats.

To read the full article Peer-reviewed Article PDF image

Author(s): Khalil Pourkhalili Mehdi Mohebbi Mahnaz Kesmati G Hossein Mohebbi Samad Akbarzadeh and Zahra Akbari


Nandrolone decanoate, Nociception, Β-endorphin, Met-enkephalin, Exercise- induced hypoalgesia., steroid

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version