alexa Abstract | The effect of increasing blood glucose level on several atherogenic factors with biomolecular in diabetes mellitus type II patients

Journal of Chemical and Pharmaceutical Research
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Abstract

Hyperglycemia in type 2 diabetes results in excessive production of superoxide in mitochondria damage, poly ADP ribose polymerase activity and inhibition of glyceraldehide-3 Phosphate Dehidrogenase. These give raise to complicated reaction in the form of polyol pathway. Protein Kinase C (PKC) activation, increasing hexosamine Advanced Glycation End Products (AGES). Expression of several molecules intracellular Adhesive Moleculs-1 leads to endothelial dysfunction. This study aims analyzing several atherogenic factors arising from the increase of blood glucose level in people with diabetes mellitus of type 2. Observational research with comparative sectional study in patient with diabtes mellitus of type 2 aged 30 – 60 years has been conducted. Sample of the research were conducted at 70 participants. Examination of PARP and ICAM-1 were conducted by Linked Immunosorbent Assay (ELISA) technique. Data were analyzed statistically by using t-test and chi-square. The mean of PARP activity in the type 2 DM group was 457 ± 81.34 Unit/μl, in non DM group it was 214 ± 75.54 Unit/μl. Mean of ICAM-1 concentration in DM group of type 2 was 670,.93 ± 192.44 ng/ml and in non DM group it was 360.01 ± 137.56 ng/ml. concentration in DM group of type 2. There was a significant correlation between the increasing of PARP activity and the increasing of ICAM-1 concentration. In addition, there was also a significant correlation between PARP activity. ICAM-1 is atherogenic factors.

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Author(s): Eti Yerizel and Asman Manaf

Keywords

type 2DM, hyperglycemia, endothel, PARP, ICAM-1., atherogenic factors

 
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