alexa Abstract | The effect of milling process on acyclovir inclution complex with beta cyclodextrin

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Acyclovir (ACV) is an antiviral drug used for the treatment of herpes simplex virus infection (HSV) and varicella zoster virus infection (VZV). One of the problems in acyclovir formulation is low solubility in water. The objective of this study is to find out the influence of milling time toward inclusion complex’s character that being formed between ACV and β-cyclodextrin (β-CD). The milling process used ball mill with variation of time in 1 hour, 3 hours, 6 hours. Preparation of inclusion complex used kneading method in 1:1 molar ratio. The characters of ACV- β-CD inclusion complex observed by using X-ray Powder Diffraction (XRD), Differential Thermal Analysis (DTA), Fourier Transform Infra-Red (FTIR), Scanning Electron Microscopy (SEM) and dissolution profile. In the dissolution profile observed a decreasing of dissolution rate on milled ACV inclusion complex compared with ACV inclusion complex without milling. Milling process create aggregation which is decreases the dissolution rate of inclusion complex.

To read the full article Peer-reviewed Article PDF image

Author(s): Deni Noviza Dedi Afrianto Erizal and Auzal Halim

Keywords

acyclovir, β-cyclodextrin, milling, kneading, inclusion complex.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords