alexa Abstract | The effects of concentration on the bio-activity of novel 1-phenyl-N-[(1E,2E)-3-phenylprop-2-en-1-ylidene]methanamine schiff base complexes of Copper(II), Nickel(II), Iron(II), Cerium(III) and Gadolinium(IV)

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


In this study, a novel 1-Phenyl-N-[(1E,2E)-3-Phenylprop-2-en-1-ylidene]Methanamine Schiff base ligand as well as its complexes with copper(II),nickel(II),Iron(II),cerium(III) and gadolinium(IV) metals were synthesized using trans-3-Phenyl-2-Propenal and α-AminoTulene as starting materials in acid medium which was followed by complexation reaction. Both the ligand and metal complexes were characterized by using spectroscopic techniques. The bio-activity of the metal complexes were assay on micro-organisms such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhii, Aspergillus niger and Candida albicans to ascertain its anti-microbial effects by varying the concentration of the metal complexes. Analysis of variance (ANOVA) was used to determine the effects of varying the concentration of the complexes on the microbial activity and on the measured zone of inhibition. Experimental results reveal that the first row transition metals under study: CU2+, Fe2+, Ni2+ are all significant at 5% level of significance while the lanthanides: Ce3+ and Gd4+ are not. An Increase in concentration of Cu2+, Fe2+ and Ce3+ complexes produced a corresponding increase in antimicrobial activity. Varying the concentration of Ni complex has no significant effect as the complex destroys completely the organisms at all levels of concentration while Gd4+ complex show little antimicrobial effect on tested organisms at varying concentration.

To read the full article Peer-reviewed Article PDF image

Author(s): Ubani O C Ngochindo R I and Odokuma L O


Schiff base, Metal complexes, Concentration, Antimicrobial activity, Bacteria, Fungi., bio-activity

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us