alexa Abstract | The effects of midazolam pre-medication on gastric acidity and gastric contents in children prior to anesthesia

European Journal of Experimental Biology
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The aim of this study was to investigate the effects of Midazolam pre-medication as an oral premedication on the gastric content acidity (PH) prior to anesthesia and decreasing the risk of aspiration pneumonitis. Sixty patients who were scheduled for surgery with ASA I and II (aged 1-10 years old) were randomly assigned to one of three groups. Group I (control, n=20) received nothing per oral (PO). Group 2 (placebo, n=20) received 2cc/kg of apple juice (clear fluid) .Third group (midazolam, n=20) received 0.5mg/kg midazolam with 2cc/kg apple juice. The volume of gastric content and pH were measured with a graduated syringe and pH strips, respectively (Merck Company, Darmstadt, Germany). Student T- test were used for statistical analysis. There was no statistical difference between the ages and weights. After premedication statistically significant difference was found regarding the gastric volumes in the groups (p<0.014) .In addition gastric pH had not significant difference (P<0.05) in group 3 (5.07±0.86) in comparison to group 1 (2.84±0.81). It is concluded that using midazolam premedication cannot increase gastric PH but it can decrease gastric volume and can have effect on reduction of the risk of aspiration pneumonitis during anesthesia in children prior to anesthesia.

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Author(s): Seyd Hedayatallah Akhlagh Arash Farbood Seyed Mohammadreza Hadavi Reza Raeesi Estabragh Ramita Shahabifar and Siyamak Derakhshandeh


Oral premedication, Midazolam, Sedation, Gastric content, pH, Acidity, Residual volume

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