alexa Abstract | The Expanding Role of the mammalian Target of Rapamycin Complex 2 (mTORC2) in Cellular Metabolism

Archives of Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The mammalian Target of Rapamycin (mTOR) nutrient-sensing pathway plays a fundamental role in cell growth, and proliferation, as well as in tumor metabolism. mTOR is the catalytic subunit that nucleates two functionally and structurally distinct complexes namely; mTORC1 (mammalian Target of Rapamycin Complex 1) and mTORC2 (mammalian Target of Rapamycin Complex 2). mTORC1 integrates inputs from nutrients, growth factors, and environmental cues; and transduces signals to downstream targets to promote anabolism and decrease catabolism. As such, mTORC1 is considered a master regulator of metabolism, cell growth, and proliferation. mTORC1 is activated by PI3K (phosphoinositide 3-kinases)-Akt/PKB (protein kinase B) and Ras- ERK ( extracellular signal-regulated kinase) pathways, both of which are the most common oncogenic signaling pathways activated in cancer. Recently, mTORC2 emerged as an important contributor to cellular and tumormetabolism. mTORC2 receives inputs mainly from growth factors and regulates the organization of actin cytoskeleton, cell survival, and cellular metabolism. This review focuses on the role of mTORC2 in cellular metabolism and cancer metabolism. Understanding the underpinning of mTORC2 signaling and targeting both mTORC1 and mTORC2 complexes, holds promise for regimens in cancer early detection, monitoring, and treatment.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Ghada A Soliman

Keywords

mTOR, mTORC1, mTORC2, metabolism, signal transduction, metabolic reprogramming, upstream signals, downstream targets, General Medicine

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords