alexa Abstract | The Gut Impacts Diabetic Management Tomorrow: The Recent Messages from Intestine and Microbiota

Journal of Clinical Nutrition & Dietetics
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


The number of diabetic patients tremendously increased worldwide constituting a grave health problem at present. Life style changes including high-fat highsugar diet and poor physical activity affect diabetes risk. Persistent, lowgrade inflammatory responses in obese patients with metabolic syndrome are considered to play a cardinal role in the development and progression of type 2 diabetes. Emerging experimental and clinical evidence indicates that gut dysbiosis, intestinal barrier dysfunction and resultant metabolic endotoxaemia are closely related to the inflammation, insulin resistance and finally cardiovascular events in patients with type 2 diabetes. Gut microbiome transmitted from mother to child at birth is profoundly affected by eating habits in life thereafter. In the feces of type 2 diabetics, relatively higher abundance in endotoxin producing gram-negative bacteria and lower abundance in butyrate-producing bacteria were reported. As butyrate is an important energy source and protector of intestinal barrier, its defect may enhance intestinal hyperpermeability and endotoxaemia. Inflammation in the adipose tissue provokes detrimental effects on other organs through secreted pro-inflammatory cytokines. Activation of Toll-like receptor 4 in immune cells such as macrophages evokes inflammation and insulin resistance, finally leading to an impairment of insulin signalling and β-cell failure. Inflammatory changes in the arterial vessels and liver lead to two life-threatening states, ischemic heart disease and liver cirrhosis, respectively. Meticulous management strategies to improve gut dysbiosis may pave the way for effective pharmacotherapy and lower the morbidity and mortality of type 2 diabetes. Biguanide derivative metformin is known to have an anti-inflammatory effect in addition to its glucoregulatory function. There is a possibility that two newly developed diabetic drugs, dipeptydilpeptidase- 4 (DPP-4) inhibitors and sodium-glucose co-transporter 2 (SGLT2) inhibitors, may have some undetermined effect on inflammation, which is worth investigating. This review summarizes the bulk of latest information on type 2 diabetes, endotoxaemia and gut dysfunction.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Hiroshi Fukui


Type 2 diabetes, Gut dysbiosis, Intestinal permeability, Endotoxaemia, Inflammation, Prognosis, Dietary therapy, Metformin, Dipeptydil-peptidase-4(DPP-4) inhibitors, Sodium-glucose cotransporter (SGLT)-2 inhibitors, Health, Diet

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version