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Background: Diabetes mellitus is global metabolic disease that increases continuously. It is usually divided into two main categories; type 1 and type 2 diabetes mellitus.
Aim: The aim of study to evaluate the physiological response of cells in STZ and STZ/HFD animal models for both types of diabetes.
Main methods: Twenty-four male Wistar rats were divided into 4 groups (6 rats /group): control for T1DM, diabetic type 1, control for T2DM and diabetic type 2. The diseases induced by single dose of streptozotocin (60 mg/kg, i.p) T1DM and HFD for 4 weeks previously the injection with streptozotocin (30 mg/kg, i.p) for T2DM.
Results: Type 1 diabetic group groups showed higher defect in the body weight, hotplate period, insulin, AST, ALT, MDA and GSH, while type 2 diabetic group showed higher defect in G6PD and GGT.
Conclusion: The two models of diabetes revealed that the cells in T1DM prefer to use glycolysis pathway, while the cells in T2DM prefer pentose pathway, which might be relevant in the real human diabetes mellitus.
Diabetes mellitus, Streptozotocin,Obesity, Insulin resistance, Phtsiology