alexa Abstract | The Syrian Golden Hamster as a Model to Study Flexal Virus Pathogenesis

Archives of Clinical Microbiology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Background: Arenaviruses are negative strand RNA viruses that can cause disease and hemorrhagic fever in humans. Flexal virus (FLEV) is a New World arenavirus that was isolated in Brazil from the Oryzomys ssp. (Rice rat). This virus is classified as a HHS and USDA Select Agent and is known to be a human pathogen that has caused mortality in humans. Currently, there has not been a description of an animal model to study FLEV induced pathogenesis. Therefore, this study aimed to characterize an animal model to study FLEV pathogenesis.Methods and Findings: In this study, we infected hamsters 5-6 weeks of age and 13-15 weeks of age) and guinea pigs with FLEV. The results demonstrate that there are discernable differences associated with FLEV infection in these 3 animal models. FLEV infection in 5-6 week old Syrian golden hamsters resulted in 60% mortality, while infection in the 13-15 week old hamsters resulted in 80% mortality. Infection in guinea pigs resulted in only 20% mortality. FLEV infection in hamsters resulted in hemorrhagic fever manifestations, which included morbidity, weight loss, petechial rash, and hemorrhage. Additionally, FLEV was isolated in specific tissues from the terminal hamsters and viremia was measured in terminal samples. Vascular leakage was associated with the lung, spleen, intestines, brain, heart, kidney, and pancreas in terminal hamsters. Lastly, mortality appeared to correlate with viral tissue titers and viremia.Conclusions: In all, this study demonstrates that the Syrian golden hamster serves as an appropriate animal model to study FLEV-induced pathology and vaccine and therapeutic efficacy

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Eric M Vela Marcus L Carlton Rebecca A Gillespie Jennifer Garver Danel Draguljic

Keywords

Medical Microbiology, Hepatitis Virus

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords