alexa Abstract | Theoretical study of O6-methylguanine-DNA methyltransferase inhibitors

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Human DNA repair protein O6 – methylguanine-DNA methyltransferase (MGMT) can provide resistance to alkylating agents by DNA damage reversal. Methylation of genes promoter may play a significant role in carcinogenesis. Hence new approaches need to be considered to enhance the inactivation of this protein in order to overcome the resistance to alkylating agents which are still some of the preferred drugs in cancer chemotherapy. In this work different mathematical models are constructed by using quantum chemical parameters and graph theoretical indices. The models are verified and it is observed that both the parameters are suitable for screening these inhibitors. This study opens the door to the development of a new generation of a MGMT inhibitors.

To read the full article Peer-reviewed Article PDF image

Author(s): Dipanjan Sarkar Subhasis Mukhopadhyay and Asim Kumar Bothra

Keywords

O6 – methylguanine-DNA methyltransferase inhibitors, regression analysis, Alkylating agents, MGMT inhibitors

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords