alexa Abstract | Theoretical study on physicochemical and geometrical properties of Doxorubicin and Daunorubicin conjugated to PEO-b-PCL nanoparticles

European Journal of Experimental Biology
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Abstract

Daunorubicin (or daunomycin) and Doxorubicin (or adriamycin or 14-hydroxydaunomycin) are well-known anticancer agents used in cancer chemotherapy. They are anthracycline antibiotics and are commonly used in the treatment of a wide range of cancers. Doxorubicin and Daunorubicin were chemically conjugated to PEO-b-PCL (poly(ethylene oxide)-block-poly(-caprolactone)) nanoparticles. In this research, the molecular structure, Binding Energy(BE), Dipole Moment (DM), Gibbs free energy of solvation (ΔG (solvation)) and some physicochemical properties of the Doxorubicin- PEO-b-PCL and Daunorubicin- PEO-b-PCL were investigated. Our results indicate that these complexes mentioned above can be used to improve the anti-cancer activity.

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Author(s): S Bagheri S M Hassani and Gh Naderi

Keywords

Anti-cancer drugs, Molecular geometry, Doxorubicin, Daunorubicin, PEO-b-PCL nanoparticles

 
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