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Research Paper Open Access
Lingha chendooram-1, a widely used Siddha drug was evaluated for acute, sub-acute and chronic toxicity in rats with reference to histopathological, haematolo'gical, parameters and detection of mercury from the tissues of liver and kidney, The drug showed acute toxicity from 100 mg onwards. But it produced sub-acute and chronic toxic effects from 50 mg onwards and elevation In blood urea level. Feed and water intake failed to reveal any marked changes in sub-acute and chronic toxicity studies. Mercury was detected from 75 mg with concurrent increase in dose in both sub-acute and chronic toxicity studies. The histopathological lesions were non-specific when compared to microscopic changes along with the drug dosages. In the present study the drug possessed no toxic effect below 20 mg.
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Author(s): A Anoop M Jegadeesan S Subramaniam