alexa Abstract | Transdermal Aspirin : Influence Of Platelet Aggregation And Serum Lipid Peroxides

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


Aspirin (ASP) inhibits H cyclo-oxygenase (COX) irreversibly and hence thromboxane A2 (TXA2) to prevent platelet aggregation. Orally administered ASP requires high and frequent dosing because it undergoes extensive presystemic hydrolysis in the gut and the liver into salicylic acid (SAL) which is devoid of antiplatelet activity. Continuous exposure of new platelets to ASP is necessary to achieve prolonged inhibition of platelet aggregation. We developed a matrix type transdermal patch of ASP using polyvinyl alcohol (with and without hydrolysis Inhibitor and a penetration enhancer). The transdermal flux of ASP, in rat skin was 11.85 and 52.92μg/cm2.h without and with penetration enhancer respectively. Transdermal administration in human volunteers resulted in a significant reduction in serum lipid peroxides (MDA levels: 0.998±0.899 to 0.236±0.076 nM/ml) and inhibition of platelet aggregation.

To read the full article Peer-reviewed Article PDF image

Author(s): D R Krishna A G Srinivas A Srinivas

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version