alexa Abstract | Transdermal delivery of trazodone hydrochloride from acrylic films prepared from aqueous latex

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

Trazodone hydrochloride has not been previously investigated and reported for potential administration through transdermal route. Therefore, the present investigation was carried out to study the effect of polymeric composition, drug content and plasticizer on the permeation of trazodone hydrochloride across the mouse epidermis for the development of transdermal therapeutic system. The pseudolatex films with different combination of polymers, plasticizer and drug were prepared from aqueous colloidal polymer dispersions. The polymers used were Eudragit RL100 and RS100. Triethylcitrate was used as plasticizer. The in vitro release and skin permeation through mouse epidermis from the prepared films were studied using Keshary-Chien diffusion cell. The in vitro drug release increased with increasing amount of Eudragit RL100 in the film. It was observed that the maximum skin permeability was attained at a loading dose of 10% w/w in the film. The in vitro flux decreased gradually at higher concentration up to 13% w/w. The present study has demonstrated the potential of the fabricated pseudolatex transdermal films for sustained release of trazodone hydrochloride. The concentration of triethylcitrate in the film markedly affected the skin permeation properties of trazodone hydrochloride.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): MK Das A Bhattacharya SK Ghosal

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords