alexa Abstract | Trypanocidal activity of a thioacyl-thiosemicarbazide derivative associating both immunostimulating thalidomide and anti-parasitic thiosemicarbazide pharmacophores

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access

Abstract

African trypanosomiasis remains a life-threatening disease and there is nowadays an urgent need for improved therapeutic agents for this pathology. In this context, in order to create novel anti-protozoa prototype containing both a trypanocidal thiosemicarbazide moiety and an immuno-potentiating thalidomide-like, a hybrid structure was designed on the basis of a convergent synthesis process, synthesized and assayed for its potential trypanocidal activity. Initial biological results are very promising. The structure of the target compound was ascertained on the basis of 13C-NMR, IR spectroscopy and semi-empirical AM1/PM3 quantum-mechanical calculations.

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Author(s): Urbain C Kasshin Fernand A Gbaguidi Christopher R McCurdy and Jacques H Poupaert

Keywords

Trypanocidal activity, immunostimulating thalidomide, thioacyl-thiosemicarbazide, thiosemicarbazide pharmacophore, Schotten-Baumann thioacylation reaction., thiosemicarbazide

 
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